System Shock 2 Medsci Armory
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2) Immune Function: It is well-recognized that during aging the overall immune system exhibits a reduced capacity to respond to perturbations. This is clearly associated with a progressive decline in thymic function. However, the degree to which the immune system is dysfunctional has not been well characterized. This is in part due to the heterogeneity of the responses seen in the aged, and in part due to the complexity of the immune responses involved. Therefore, we are using our preclinical models to characterize the specific abnormalities in immune function in the aged. This has focused on B cell responses, as these are key to generation of novel pathogen-specific antibodies. We are also actively investigating the role of innate immunity in this process. Finally, we are also investigating the ability of vaccination and treatment with immunoregulatory agents to restore immune function in the aged.
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