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The aim of this study was to investigate whether free radical reactions or alkaline phosphatase activity of bone marrow during the course of acute lymphoblastic leukaemia (ALL) differed from controls. The levels of malondialdehyde (MDA), reduced glutathione (GSH) and superoxide dismutase (SOD) were determined in blood and bone marrow samples collected from 30 patients and 10 controls at diagnosis, after four cycles of chemotherapy and at remission. The activities of the alkaline phosphatase (ALP) were measured using standard methods. All the groups showed a significant increase in MDA levels in blood and bone marrow samples and in ALP activity in the blood compared to controls (p Chronic neuropathic pain is a common symptom of many diseases and injuries, and may be associated with other symptoms and/or physical 0b46394aab